Artists, sculptors, and photographers featured in the collection include Alice Aycock, Charles Hinman, Chul Hyun Ahn, John Safer, Liao Yibai, Margaret Boozer, Martha Jackson Jarvis, Sam Gilliam, and Terry O'Neill. The resort's public spaces feature a permanent collection of art inspired by the Washington metropolitan area and developed in collaboration with Prince George's County Arts and Humanities Council, Atlantic Arts, and RareCulture. MGM National Harbor includes a 23-story hotel with 308 rooms, 135,000 square feet (12,500 m 2) in gaming space, retail space, a spa, seven restaurants, a 3,000-seat theater with seven VIP suites, 27,000 square feet (2,500 m 2) of meeting and event space, and a parking garage for 4,800 cars. while the architect of record for the project is SmithGroupJJR.

The organization of the casino is along a central axis, similar to the arrangement for the National Mall. The white exterior of the building is in keeping with the marble used in many of the buildings in Washington DC. In April 2015, the MGM casino was sued by a group of Prince George’s County businesses who claimed the casino didn't comply with minority business enterprise (MBE) contracting standards. Construction on MGM National Harbor began in April 2014, and opened on December 8, 2016.

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